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KMID : 0379520190350040353
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한국독성학회지
2019 Volume.35 No. 4 p.353 ~ p.359
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Alleviation of Ultraviolet B-Induced Photoaging by 7-MEGATM 500 in Hairless Mouse Skin
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Park Kyo-Hyun
Kim Ji-Yeon
Jung Su-Ryun
Sung Kyung-Hwa
Son Yeon-Kyoung
Bae Jung-Min
Kim Bae-Hwan
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Abstract
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The purpose of this study was to investigate the effect of 7-MEGATM 500 on the improvement of skin aging in an UVB-induced photo-aging model of hairless mice. The dorsal skin of hairless mice was exposed to UVB three times a week for 12 weeks to induce skin wrinkle. After inducing the wrinkle, 7-MEGATM 500 was orally administered once a day for 4 weeks. Skin thickness, skin barrier function, and wrinkle indicators were improved by treatment with 7-MEGATM 500. Both gene and protein expression levels of MMP-3 and c-Jun in skin were significantly decreased by 7-MEGATM 500. Therefore, the intake of 7-MEGA TM 500 is thought to have a positive effect on the improvement of skin aging, although further studies are needed.
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KEYWORD
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7-MEGATM 500, Photoaging, Hairless mice, c-Jun, MMP-3
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